Exercise intolerance in heart failure with preserved ejection fraction: shifting focus from the heart to peripheral skeletal muscle.

Can Nitrite AMPk Up Sirt-ainty to Treat Heart Failure With Preserved Ejection Fraction?

692 Heart failure with preserved ejection fraction (HFpEF) remains a common yet vexing clinical syndrome, with no approved therapies despite prevalence, morbidity, and mortality on a par with those of heart failure with reduced ejection fraction. Therapies and devices proven effective in heart failure with reduced ejection fraction have repeatedly fallen short in their application to HFpEF. Thi...

Exercise intolerance in patients with chronic heart failure.

Patients with chronic heart failure (CHF) experience significant morbidity because of dyspnea and fatigue with activities of daily living. Although central hemodynamic abnormalities are the hallmark of this disorder, investigators have not shown a relationship between left ventricular ejection fraction or exercise pulmonary capillary wedge pressure and exercise intolerance in this disorder. Rec...

Making the Case for Skeletal Muscle Myopathy and Its Contribution to Exercise Intolerance in Heart Failure With Preserved Ejection Fraction.

HIGHLIGHTED TOPIC Exploring New Concepts in the Management of Heart Failure with Preserved Ejection Fraction: Is Exercise the Key for Improving Treatment? Soothing the sleeping giant: improving skeletal muscle oxygen kinetics and exercise intolerance in HFpEF

Sarma S, Levine BD. Soothing the sleeping giant: improving skeletal muscle oxygen kinetics and exercise intolerance in HFpEF. J Appl Physiol 119: 734–738, 2015. First published June 5, 2015; doi:10.1152/japplphysiol.01127.2014.—Patients with heart failure with preserved ejection fraction (HFpEF) have similar degrees of exercise intolerance and dyspnea as patients with heart failure with reduced...

PARIS: A good start for exercise in HFPEF

INTRODUCTION Heart failure (HF) is a complex clinical syndrome characterized by a constellation of signs and symptoms involving various organ systems. Structural and/or functional cardiac abnormalities form a cornerstone to the pathophysiology of HF. However, extracardiac dysfunction plays an equally important role in its development and progression. Approximately 50% or more of HF patients hav...